The first of the Buddha’s Four Noble Truths pointed to us the truth of suffering. Suffering needs to be recognized as such and faced head-on if we wish to truly alleviate it. Our efforts to deny it or indulge in sensory indulgences to distract ourselves from it will inevitably lead to more suffering.
In the Second Noble Truth, the Buddha dives deeper to untangle the cause of this state of dukkha, this unsatisfactoriness that is the mark of samsara. He points to two root causes for suffering: craving (tanja) and ignorance (avijja). These, in turn, are related to the three poisons: hatred, ignorance, and greed.